Asphalt concrete used in pavements is a composite of asphalt binder, crushed aggregate, and air voids. In order to study the microstructure of asphalt concrete, image processing and analysis techniques are very essential since image analysis has the advantage of simplicity and accuracy in capturing microstructural features. In this study, the asphalt concrete microstructure was captured by study the two-dimensional (2D) image. These images were processed using a comprehensive image processing package - Image Pro Plus 5.0. The particle shapes, orientations, and coordinates of the aggregate and mastic were recorded through the package with some user defined macro-codes. An MDEM modeling approach was then used in the microstructural response prediction such as complex modulus and creep compliance as well as tensile strength of asphalt concrete.